Details objective and subjective information on how heroin changes brain cells and impacts cognition, judgment and rational behavior. Viewers learn that variations on this opiate have been in use by humans for 5000 years - offers a comprehensive historical, scientific, and psychological analysis. Reasons for its long term popularity are explained as its pleasurable / addictive nature becomes clear. Interviews with recovering users fill in the details as to how the first pleasures from the drug quickly began to elude them and turned into a 24/7 nightmare that wouldn't go away.