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This program comes to grips with depression through the experiences of five patients whose backgrounds span the socioeconomic spectrum. Three cases of chronic depression, one of which is complicated by borderline personality disorder and another by alcohol abuse, and two cases of bipolar disorder, one of which is extreme, are presented. The overarching message? Patients with depression can stabilize and lead fulfilling lives if they accept their condition and proactively address it. Antidepressants, psychiatric therapy, acupuncture, and other modalities are touched upon as components of a tailored treatment plan.